The 2027 Mercedes-Benz E 450 4MATIC® Sedan is where the E-Class begins to feel genuinely effortless. Its 3.0-liter turbocharged inline-six produces 375 horsepower and 369 lb-ft of torque, enough to cut the 0–60 mph run to 4.4 seconds while retaining the quiet, composed personality expected of Mercedes-Benz longstanding midsize luxury sedan. Standard 4MATIC® all-wheel drive gives the E 450 year-round traction, and its 48-volt mild-hybrid system adds electric assistance without requiring the driver to plug in or alter daily habits.
The inline-six is central to the E 450’s character. Its inherently smooth layout is paired with a twin-scroll turbocharger, CAMTRONIC variable valve lift and Mercedes-Benz Integrated Starter-Generator. The ISG can add electric assistance when needed, recapture energy during deceleration and allow periods of gas-free coasting. A 9G-TRONIC nine-speed automatic transmission handles power delivery, and the result is a sedan that has considerably more muscle than the four-cylinder E 350 without moving into AMG® territory.
That extra performance does not come with an outsized fuel penalty. EPA estimates are 22 mpg city and 31 mpg highway. The standard suspension uses a four-link front and five-arm multilink rear arrangement with selective damping, while available AIRMATIC® suspension, Adaptive Damping System Plus and 4.5-degree rear-axle steering give buyers the opportunity to make the E 450 even more sophisticated. Rear steering is especially useful in a car nearly 195 inches long, reducing the effort required in parking structures and other tight spaces.
The cabin continues the E-Class emphasis on digital technology without losing the comfort expected in this part of the Mercedes-Benz range. MBUX Augmented Video for Navigation uses a forward-facing camera to display a live image of the road and superimpose directional information over it. DISTRONIC® adaptive cruise control can adjust speed according to traffic ahead, while available technology extends the E-Class’s driver-assistance capabilities further. AMG® body styling gives the E 450 a sharper exterior appearance than its restrained luxury-sedan proportions might suggest.
For Chicago and North Shore drivers, the E 450 has an unusually broad operating range. It has the acceleration to feel legitimately quick, the all-wheel-drive traction to make that performance useful through four seasons and a 31-mpg highway rating that keeps it sensible on long interstate trips. Starting at $73,700, the 2027 E 450 4MATIC® Sedan sits between the four-cylinder E-Class models and the AMG® E 53 HYBRID, and that middle position suits it exceptionally well.
Features of the 2027 Mercedes-Benz E 450 4MATIC® Sedan

3.0-Liter Turbocharged Inline-Six
The E 450’s smooth inline-six produces 375 horsepower and 369 lb-ft of torque, delivering substantially stronger acceleration than the four-cylinder E 350 models.

Mild-Hybrid Integrated Starter-Generator
The 48-volt ISG can provide electric assistance, recover energy during deceleration and support gas-free coasting, adding efficiency and responsiveness without requiring external charging.

4MATIC® All-Wheel Drive
Standard 4MATIC® continuously distributes power among all four wheels, providing additional traction on wet pavement, snow and other changing road surfaces.

9G-TRONIC Transmission
Mercedes-Benz nine-speed automatic provides a wide spread of ratios for quick acceleration and relaxed highway cruising.
DYNAMIC SELECT
Selectable drive programs alter powertrain and vehicle responses so the driver can tailor the E 450 to different roads and driving situations.

Available AIRMATIC® Suspension
Optional air suspension works with Adaptive Damping System Plus to continuously adjust damping and help maintain a composed ride over changing pavement.

Available Rear-Axle Steering
The optional 4.5-degree rear-steering system improves maneuverability at lower speeds while contributing to stability during higher-speed driving.
DISTRONIC® Adaptive Cruise Control
Radar-based DISTRONIC® can automatically adjust the E 450’s speed according to traffic ahead and can bring the vehicle to a stop when traffic requires it.
MBUX Augmented Video for Navigation
Live imagery from a forward-facing camera can be displayed on the central screen with navigation arrows, street information and other guidance superimposed over the approaching road.
AMG® Body Styling
Sculpted front and rear treatments and sportier exterior detailing give the E 450 a more athletic visual character.
Quick Answers
The 2027 Mercedes-Benz E 450 4MATIC® Sedan starts at $73,700 and uses a 3.0-liter turbocharged inline-six with mild-hybrid technology producing 375 horsepower and 369 lb-ft of torque. Standard equipment includes 4MATIC® all-wheel drive and a 9G-TRONIC nine-speed automatic. Mercedes-Benz estimates 0–60 mph in 4.4 seconds, while EPA fuel economy is rated at 22 mpg city and 31 mpg highway. The E 450 seats five and provides 12.7 cubic feet of trunk capacity.
Frequently Asked Questions
How much does the 2027 Mercedes-Benz E 450 4MATIC® Sedan cost?
Starting MSRP is $73,700.
What engine does the 2027 E 450 use?
It uses a 3.0-liter turbocharged inline-six with mild-hybrid drive.
How much horsepower does the E 450 have?
The engine produces 375 horsepower and 369 lb-ft of torque.
How fast is the 2027 E 450 4MATIC® Sedan?
Mercedes-Benz estimates 0–60 mph in 4.4 seconds.
Does the E 450 have all-wheel drive?
Yes. 4MATIC® all-wheel drive is standard.
What is the fuel economy of the E 450?
EPA estimates are 22 mpg city and 31 mpg highway.
How much trunk space does it have?
Mercedes-Benz lists cargo capacity at 12.7 cubic feet.
Key Specifications
Starting MSRP: $73,700
Engine: 3.0L inline-six turbo with mild-hybrid drive
Horsepower: 375 hp
Torque: 369 lb-ft
Transmission: 9G-TRONIC nine-speed automatic
Drivetrain: 4MATIC® all-wheel drive
0–60 mph: 4.4 seconds
Fuel Economy: 22 city / 31 highway mpg
Passenger Capacity: 5
Cargo Capacity: 12.7 cu ft
Fuel Capacity: 17.4 gallons
Wheelbase: 116.6 inches
Overall Length: 194.9 inches
Expert Summary
The 2027 E 450 4MATIC® Sedan combines the E-Class’s comfort and technology with the smooth power of a turbocharged inline-six. Its 4.4-second sprint to 60 mph gives it serious performance, while standard 4MATIC®, strong highway efficiency and available AIRMATIC® suspension make it equally convincing as an everyday luxury sedan.
About Loeber Motors
Loeber Motors is your premier Mercedes-Benz dealer in the Chicago area, serving Lincolnwood, Evanston, Skokie, and the North Shore. Our team of Mercedes-Benz experts is ready to help you explore the full 2027 lineup. Visit us, call, or configure your vehicle online today.
Discover the 2027 Mercedes-Benz E 450 4MATIC® Sedan at Loeber Motors.
Schedule a Test DriveBase MSRP excludes transportation and handling charges, destination chargers, taxes, titles, registration, preparation and documentary fees, tags, labor and installation charges, insurance, and optional equipment, products, packages and accessories. Options, model availability and actual dealer price may vary. See dealer for details, costs, and terms. *Bluetooth is a registered mark of Bluetooth SIG, Inc
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*Base MSRP excludes transportation and handling charges, destination charges, taxes, title, registration, preparation and documentary fees, tags, labor and installation charges, insurance, and optional equipment, products, packages and accessories. Options, model availability and actual dealer price may vary. See dealer for details, costs and terms. **Stated rates of acceleration are estimated based upon manufacturer’s track results and may vary depending on model, environmental and road surface conditions, driving style, elevation and vehicle load.